Genetic and Epigenetic Features of Uveal Melanoma—An Overview and Clinical Implications

Uveal melanoma (UM) is rare, but it the most common primary intraocular malignancy among adults. This review represents molecular, genetic, and immunobiological mechanisms involved in UM carcinogenesis progression, as well data about association of chromosomal changes, genetic mutations, selective proteins, biochemical biomarkers with clinical implications UM. Genetic analysis has potential to identify patients a high risk metastasis, enabling management that more effective allowing for follow-up patients. Advancements molecular characterization offer opportunities develop targeted therapeutic strategies by focusing on relevant signaling pathways. Changes miRNA expression could be useful diagnosis prognosis UM, due unique profiles cells or tissue its metastasis. Although liver function tests do not provide enough frequency (LFTs) might indicators; however, absence rising LFT values cannot lead exclusion metastases. Molecular tumor will allow us added benefit new agents better insight into pathogenesis biological behavior.